Best Once Human Acid farm

The ultimate Once Human Acid farm guide

Create plenty of Acid passively to keep up with ammunition production

In Once Human, Acid is an important resource as it is used in a lot of crafting recipes and one of the more predominant materials involved in crafting specialty Ammunition that can deal with end-game bosses. We’ve put together the best Once Human Acid Farms so you can get as much of it as you may need for crafting.

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How to farm Acid in Once Human

There are multiple ways to farm acid in Once Human, both actively and passively. As you might expect, active farms will get you acid faster, but won’t be as effective in the long run. Passive methods will be slower, but will add up quickly and could get you all the Acid you could ever need.

So let’s take a look at all the ways you can farm Acid, starting with the active methods.

The best active Acid farms in Once Human

Method 1: Refineries

Using this method, you could collect upwards of 1,000 Acid per hour, but it is a bit of a grind. This method involves using one of the game’s many refineries. The first thing to do if you’re going to grind refineries is to make Deviated Chops, which helps boost the Acid drop rate.

Preserved Deviated Chops being prepared at a Kitchen Set in Once Human for Acid farming.
Screenshot by Destructoid

You can craft Preserved Deviated Chops at an Electric Stove or Kitchen Set, and you’ll need one of any meat, one peppercorn, and two salt.

Now you’ll want to find a refinery. My favorite one is at the Blackfell Oil Fields, which can be found by looking for the refinery icon, as depicted below.

The Refinery icon highlighted on a map in Once Human.
Screenshot by Destructoid

Walk up to the production facilities, interact, choose the card you want, and start the defense. Be warned, however, that the level 45 monsters can be quite challenging.

A player starts the Refinery defense mission in Once Human in order to farm Acid.
Screenshot by Destructoid

If you don’t have a strong build, be sure to enter build mode and block all the entrances before you rush the start of the defense.

In just one run, I managed to get over 200 Acid, and an average run takes about 7 minutes in total to complete. This means that you can easily get more than 1,000 Acid per hour, or even per half-hour if you’re lucky ā€” all while your passive Acid farm is generating even more back at home.

The amount of Acid gained in one Refinery Defense displayed and highlighted in the player's inventory in Once Human.
Screenshot by Destructoid

Keep in mind that the majority of your Acid comes from the mobs you defeat, so be sure to pick up all the loot as you go.

Method 2: Deviant Locations (if Refineries are too difficult)

Ashenton in the distance in Once Human, a great spot for Acid Farming.
Screenshot by Destructoid

This method will also start with you making and consuming Deviated Chops. All active Acid farms in Once Human will start with these chops, so keep this in mind.

For this method, you’ll need the highest level area that has the Deviant enemy type that you can find. So head to an area like Ashenton in the Way of Winter, or Blackfell in the Manibus scenario, and circle the city, killing all the Deviants you see. Make sure to grab the loot they leave behind, as this is how you’ll be gaining Acid.

Both these cities can only be accessed in Phase 2, I should add.

But what’s better than farming a ton of Acid while fighting Deviants? That’s right; you can farm acid even while you sleep. Let’s move on to the passive farming methods.

Best Passive Once Human Acid farms

Method 1: Pollution Zone farm

A Brewing Barrel in Once Human, producing Acid from Impure Acid and Purified Water.
Screenshot by Destructoid

The best Once Human Acid farm involves setting up a passive farm at your base that will automatically generate Acid for you to use. Primarily using Water Pumps, this passive farm can generate 288 Acid per day for a mere 108 Watts of power.

It’s important to note that Acid can only be created in polluted areas, so make sure you are in one when setting up the passive Acid farm. If you see a number fluctuating on your character’s back, you are in a polluted area. Here’s what you’re going to need to build this passive Acid farm in Once Human:

  • 10 Water Pumps
  • 1 Osmosis Water Purifier
  • 1 Fermentation Barrel
  • 108 Watts of Power
  • Build in a Pollution Zone

Build the most advanced generators that you can, with Deviation Energy Generators offering the most power output. If you have a specialization for the other generators, they may prove more efficient. You can unlock these generators in the Logistics branch in your memetics screen.

Next, construct your 10 Water Pumps, which are also found under Logistics (in 03) in your Memetics screen. Make sure you raise the elevation using Alt and the scroll wheel when placing the Water Pumps so that water can flow downwards to your filters. Each Water Pump you build requires the following materials:

  • 25 Steel Ingot
  • 20 Carbon Fiber Fabric
  • 20 Refined Parts
  • 20 Standard Parts
  • 20 Electronic Accessory
  • 10 Watts of Power

Make sure all the Water Pumps are dumping into Water Storage Containers. From here, connect the other side of the Water Containers to an Osmosis Water Purifier. The Osmosis Water Purifier will convert the Polluted Water into Impure Acid.

You’ll have to manually collect the Impure Acid out of the Water Purifier, which you then place into a Brewing Barrel. A completely filled Brewing Barrel will generate 4 Acid every 20 minutes, making this passive base the best Once Human Acid farm!

Method 2: Corrupted plants

Contaminated Aloe Vera in Once Human, used for Acid production.
Screenshot by Destructoid

Within pollution zones, you can find contaminated plants. These can also be refined in a Brewing Barrel and be made directly into Acid (without having to go through a Water Purifier). However, to be efficient with this method, you’ll need to find seeds and plant these crops.

This means irrigating them, ensuring they have enough light and harvesting and replanting them (unless you have a Growshroom). However, this method isn’t quite as effective as our first method.

Method 1 remains the best passive Acid farm in Once Human.

Method 3: Thermal Towers Acid Farm

Thermal Tower interface in Once Human, with the acid production perk, Chaosium Chemistry, highlighted by an arrow.
Screenshot by Destructoid

The Way of Winter Scenario has given us one more method with which to farm Acid ā€” by simply building and upgrading a Thermal Tower. You can unlock the Thermal Tower under the Building tab in 04 in your Memetics Screen. It costs 2000 Energy Links and 7 Ciphers to unlock.

You’ll then have to build one on a neighboring plot to your house, and building it will require the following.

  • 35 Aluminium Ingots
  • 50 Steel Ingots
  • 30 Metal Scraps
  • 30 Electronic Parts
  • 10 Storage Batteries

Once done, you’ll need to begin upgrading it. The first few tiers won’t cost too much and only take five minutes. Once you can build from the second tier, Thermostatic Cover, you’ll be able to choose Chaosium Chemistry, after which your tower will produce 50 Acid every day.

That doesn’t sound like much, but our level 28 tower is producing about double that, somehow. At around 1200 Acid per day, you won’t be needing Acid for much longer.


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Steven Mills
Staff Writer - Steven has been writing in some capacity for over a decade now. He has a passion for story focused RPG's like the Final Fantasy franchise and ARPG's like Diablo and Path of Exile. But really, he's willing to try anything.
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Kyle Ferreira
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