Warframe Mesa Prime
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Best Mesa Prime build in Warframe

I've got 180 rounds in this six-round magazine, partner.

Before bringing your frames in Warframe to mid-late game content, you’ll want to figure out a good mod build. These mods completely change how the frame functions, and can skyrocket its potential for helping your team or taking down enemies.

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One such frame that’s used by a lot of people has a unique build to spec into. Here’s the best build for Mesa Prime in Warframe.

The best mods and Arcanes for Mesa Prime in Warframe

Warframe Mesa Prime Build
Image via Destructoid.

All of Mesa Prime’s abilities are solid, but her fourth ability, Peacemaker, is easily her best. The raw damage output from the pistols is massive, and thus we want to focus on improving its stats. The following mods do just that:

  • Growing Power (Aura)
  • Power Drift (Exilus)
  • Fleeting Expertise
  • Adaptation
  • Umbral Intensify
  • Vitality
  • Primed Flow
  • Narrow Minded
  • Continuity
  • Transient Fortitude

These mods will increase Mesa’s base Ability Duration, Efficiency, and Strength while lowering her Range. Since Range doesn’t affect her ult or much in the way of her abilities, it can safely be reduced. Otherwise, the Duration and Efficiency help slow the Energy drain. Vitality and Adaptation are added to give Mesa a bit of survivability since she’s a bit of a glass cannon otherwise. If you want to Subsume one of her abilities, a common choice is to replace her first ability, Ballistic Battery, with Grendel’s Nourish. Since having a single shot do increased damage isn’t great in most scenarios, the added survivability far outweighs its usefulness.

Moving over to Arcanes, the best two are Arcane Energize and Arcane Avenger. Arcane Energize is good on any frame thanks to keeping that energy value nice and high at all times. Meanwhile, Arcane Avenger grants a massive fire rate increase on pistols when hitting crits. Since your ult counts as pistols, this turns you into a fire rate machine.

What about her Regulators?

If you’re looking for a good build for her Regulators, the following mods will get the job done:

  • Galvanized Diffusion
  • Galvanized Shot
  • Anemic Agility
  • Hemorrhage
  • Primed Target Cracker
  • Lethal Torrent
  • Pistol Pestilence
  • Pistol Gambit

Barrel Diffusion and Sure Shot are decent alternatives if you don’t have the Galvanized variants. Otherwise, we’re building for Multishot and those crits, since we want a lot of those. The Toxin and Status Chance is added to help trigger the Growing Power mod we have slotted into Mesa herself. We also reduce the damage slightly using Anemic Agility, but trade that for a major increase in fire rate.


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Shawn Robinson
Shawn is a freelance writer at Destructoid who's been here and there in the industry for around five years now. His immense (and sometimes scary) level of knowledge in games helps him know the most about the titles he writes about. If he's not writing, he's probably gaming, and gaming some more.