All boss materials in Diablo 4, including the best farming locations

Diablo 4 has quite the late-game grind, and if you’re looking to summon what the community refers to as “ladder bosses,” then you’ll need to come prepared. To that end, you must collect all of Diablo 4’s boss materials before finally meeting these big bads offering Unique equipment.

That being said, here’s every Diablo 4 material you’ll need to summon their respective bosses, separated by difficulty.

Every boss material in Diablo 4

Some bosses can only be summoned in World Tier IV (Torment), while others can be summoned in Tier III at lower costs. This will be mentioned.

Grigoire, The Galvanic Saint

• Living Steel
  • 2x – World Tier III
  • 5x – World Tier IV
  • 15x – Tormented
• Best farm: Helltide Tortured gift chests.

Echo of Varshan

• Malignant Hearts
  • 2x – World Tier III
  • 5x – World Tier IV
  • 15x – Tormented
• Best farm: Helltide events and bosses, Whispers of the Dead caches.

Beast in the Ice

• Distilled Fear
  • 9x – World Tier IV
  • 27x – Tormented
• Best farm: Tier 30+ Nightmare dungeon completions.

Lord Zir

• Exquisite Blood
  • 9x – World Tier IV
  • 27x – Tormented
• Best farm: World bosses, Legion Events, and Helltide bosses.

Duriel, King of Maggots 

• World Tier IV
  • 2x Mucus-Slick Egg 
  • 2x Shard of Agony
• Tormented 
  • 6x Mucus-Slick Egg 
  • 6x Shard of Agony
• Best farm (Mucus-Slick Egg) – Echo of Varshan and World Bosses.
• Best farm (Shard of Agony) – Grigoire and World Bosses.

Andariel, Maiden of Anguish

• World Tier IV
  • 2x Pincushioned Doll
  • 2x Sandscorched Shackles
• Tormented
  • 6x Pincushioned Doll
  • 6x Sandscorched Shackles
• Best farm (Pincushioned Doll) – Beast in the Ice and World Bosses.
• Best farm (Sandscorched Shackles) – Lord Zir and World Bosses.

With all that out of the way, there is one more universal item you need if you’re trying to fight the Tormented versions of these bosses. While you need three times the amount for normal summoning materials, you need a Stygian Stone each time.

The best farm for Stygian Stones is to complete the newly introduced Infernal Hordes mode at Tier 7 and higher. Enemy levels will be significantly higher, but the best loot will start dropping around, including the Stones.